| RekenTest | South Holland |
| Relay42 | North Holland |
| Relive B.V. | |
| ReloadSEO B.V. | |
| Rely Websolutions | North Holland |
| Relyon | South Holland |
| ReMedia | Groningen |
| Remedy IT | Gelderland |
| Remind-IT | Limburg |
| RENA Electronica B.V. | North Brabant |
| Renaissance IT | South Holland |
| Renoon | North Holland |
| Reprise Digital | |
| Repsy | |
| Research Manager | Overijssel |
| Resello | Overijssel |
| Resume.io | |
| Retail Rocket | |
| RetailVista | Flevoland |
| RetSoft | |
| RetSoft B.V. | Groningen |
| Reudink Software | Drenthe |
| Reveall | |
| Revisely B.V. | |
| Revive Adserver | |
| Revo Capital | North Holland |
| Revo Capital | |
| RevSpace | |
| Reynen Court, Inc. | North Holland |
| RFID Platform Nederland | South Holland |
| RGB+ Automatisering | Overijssel |
| RheinBrücke IT Consulting B.V. | |
| Rian B.V. | North Brabant |
| Ricoh Nederland B.V. | North Brabant |
| RIFF | North Holland |
| RightClick | North Holland |
| Rijksdienst Caribisch Nederland | |
| Rijs Solutions | |
| Rinkel B.V. | |
| RIPE NCC | North Holland |
| Riscure Security Lab | South Holland |
| RIset B.V. | North Holland |
| Rita Personal Data B.V. | |
| Ritense | North Holland |
| Rits Consultancy | |
| RM Data | North Holland |
| Roald Craenen | Limburg |
| Roam.ai | |
| Roamler B.V. | |
| ROBES Informatica B.V. | Gelderland |