| Sipr | |
| SIRA | South Holland |
| Sirius B.V. | North Brabant |
| Sirius Medical Systems B.V. | |
| SiSo IT Services B.V. | Flevoland |
| Site.nu | |
| Sitelight | Gelderland |
| SiteWise | Gelderland |
| Six ICT | North Brabant |
| Sixtyseven Communicatie B.V. | North Holland |
| Skalar Analytical B.V. | |
| Sketch B.V. | |
| Skikk | Overijssel |
| SkillsCV | |
| SkinVision B.V. | North Holland |
| Skoon Energy B.V. | |
| Skyberate Internet Services B.V. | Gelderland |
| SkylineDx B.V. | |
| SlicingPSD | North Holland |
| Slimmer | |
| SLTN | North Holland |
| Smart Event Manager | Flevoland |
| Smart Grid B.V. | |
| Smart Ink | |
| SMART Photonics | |
| Smart Profile | |
| SMART Research B.V. | Gelderland |
| Smart Robotics | |
| Smart-Ship B.V. | |
| Smart.pr | |
| Smart.pr | |
| Smartchecked | |
| Smartdc | |
| SmartDocuments | Overijssel |
| SmartHOTEL | South Holland |
| Smartlockr | |
| Smartmile | |
| Smartocto | Gelderland |
| smartQare | |
| SmartRanking | Groningen |
| SmartSV | |
| Smartwares Group | North Brabant |
| Smidt Kennisprovider | Drenthe |
| SMT | South Holland |
| Snakeware | Friesland |
| Snapput B.V. | |
| SnelStart | North Holland |
| Snirp | |
| Snoeren Automation | North Holland |
| Social Blue | North Holland |